A powerful and dangerous synthetic opioid is making headlines, and it's far deadlier than many people realize.

Isotonitazene, often referred to as 'ISO', belongs to the nitazene class of opioids, a group of synthetic drugs that can be multiple times stronger than morphine and significantly more potent than fentanyl.

Since its emergence in the U.S. illicit drug supply in 2019, ISO has been linked to an alarming number of medical emergencies and overdoses. Part of what makes it so dangerous is how it can go under the radar; it's often mixed into counterfeit pills or street drugs without the user knowing. Even experienced opioid users may not realize they've taken it until it's too late.

At The Coleman Institute for Addiction Medicine, we know how urgent it is to act when dealing with substances such as Isotonitazene. Our Accelerated Outpatient Opioid Detox program can help you safely and comfortably eliminate opioids from your system in days without the need for hospitalization.

What Is Isotonitazene?

Originally synthesized for pharmaceutical research but never approved for medical use, Isotonitazene acts on the opioid receptors in the brain. These are the same receptors activated by heroin, oxycodone, and fentanyl; ISO binds to those receptors, despite being synthetic.

Why Is It Dangerous?
  • Extreme potency: Even tiny amounts can suppress breathing, cause unconsciousness, or lead to death.
  • Unpredictable risk: Since ISO is often combined with other substances, people may unknowingly ingest dangerous doses.
  • Difficult detection: Standard drug tests may not pick it up, delaying critical care in overdose situations.
Isotonitazene (ISO) is an active opioid agonist that's approximately 20 times more potent than fentanyl.

Why Quitting ISO Is Difficult

Because Isotonitazene is so potent, the body quickly becomes dependent. Stopping cold turkey can trigger severe withdrawals.

Signs & Symptoms May Include:
  • Muscle aches & body pain
  • Intense cravings
  • Restlessness & insomnia
  • Nausea, vomiting, & diarrhea
  • Anxiety, irritability, & depression
  • Sweats, chills, & flu-like symptoms
For many, these symptoms are unbearable without medical intervention, making relapse common and recovery feel out of reach.

How Accelerated Outpatient Detox Works

Traditional detox programs may require weeks in a hospital or inpatient facility. Our Accelerated Outpatient Opioid Detox is different; it's faster, more comfortable, and helps you recover without putting your life completely on hold.

Our Treatment Program Includes:
  1. Comprehensive Assessment: We evaluate your health, history, and usage to create a personalized treatment plan.
  2. Medically Supervised Detox: Over a few days, we gradually and safely remove opioids from your brain's receptors, reducing the intensity of withdrawal.
  3. Non-Addictive Medications: We use medications that control cravings and discomfort without creating new dependence.
  4. Relapse Prevention: Once the opioids have been flushed out of the system, we can start Naltrexone Therapy with Vivitrol injections, which block opioid effects and reduce the risk of relapse.
  5. Case Management: You'll have access to support during and post-detox, including follow-ups with your medical provider and referrals to continue addiction treatment (PHP, IOP, etc).

The Importance of Naltrexone Therapy

Detox is the first step, but we believe relapse prevention is critical for lasting recovery. Naltrexone works by binding to opioid receptors and blocking the effects of opioids if they are used again. This means that even if a slip occurs, the user won't experience the euphoric high that fuels the cycle of addiction.

By incorporating Naltrexone after detox, we help patients:
  • Reduces opioid cravings
  • Supports early recovery
  • Lowers relapse risk

Why People Choose The Coleman Institute

  • Faster Detox: Complete the detoxification process in days, not weeks.
  • Outpatient Convenience: Return home or to a supportive environment each night.
  • Comfort-Focused Care: Minimize withdrawal symptoms in a safe, supportive environment.
  • Proven Success: Over 25 years of experience with a 95% completion rate and thousands of patients helped across the country.
  • Naltrexone Therapy: Transition into Naltrexone Therapy for long-term sobriety right after detox.
  • Nationwide Access: Locations available in multiple states with our detox protocol.

Insurance & Payment Options

Our philosophy is that life-saving addiction treatment should be accessible.

At Our Richmond, VA Facility, We:
  • Accept Insurance
    • Anthem Blue Cross Blue Shield
    • Sentara Health Plans
  • Accept third-party financing
  • Offer self-pay rates
At our other locations in Georgia, Colorado, Florida, and California, treatment is available on a self-pay basis, with third-party financing options for those who qualify.

The Coleman Institute’s Locations

The Coleman Institute offers Accelerated Outpatient Opioid Detox at:

The Risk of Waiting to Stop

Every day with Isotonitazene use is a gamble. Because it's so potent and often hidden within other drugs, the risk of fatality is high, even for people with high opioid tolerance. The sooner you stop, the sooner you can protect yourself from becoming another statistic.

Choose Recovery Today

Recovery is possible, and it can start now. The Coleman Institute's Accelerated Outpatient Opioid Detox offers a safe, fast, and comfortable way to break free from Isotonitazene and start a new, healthier, happier chapter in life.

Call us at 877-773-3869 to speak with a recovery expert. We'll answer your questions, verify your insurance, and help you take the next step toward a brighter future.